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Amazon is offering the SiriusXM Roady BT In-Vehicle Satellite Radio Kit for $69.99 shipped. Down 30% from its normal going rate at Amazon, today’s deal marks a new low that we’ve tracked there and is also the first discount all-time at the retailer. Designed to deliver in-vehicle entertainment, the Roady BT satellite radio installs in your car and connects to your stereo through Bluetooth, 3.5mm aux, or over a built-in FM transmitter. You can choose to mount it via a magnetic vent or dash adapter and there’s an additional mounting system that’s sold separately should you need it. Plus, it comes with a three month free trial of Sirius XM or you could opt for 12 months of the brand’s Platinum Programming Package for $99. Keep reading for more.

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New paper explains why females are prone to autoimmune diseases

Published:

Cartoon of two X-shaped chromosomes.

Enlarge (credit: Rost-9D)

Eighty percent of patients with autoimmune diseases are female. These diseases are one of the top 10 leading causes of death for women under 65, and cases are increasing annually worldwide. There is evidence suggesting that it's females’ double complement of X chromosomes that puts them at such heightened risk for autoimmune diseases. Female cells have two X chromosomes, whereas males have one X chromosome and one Y chromosome (at least in mammals).

Shutting down an X

Different animals compensate for this sort of disparity in different ways. Male fly cells churn out twice the amount of the proteins encoded by their single X chromosome, so they end up with the same amount as female cells. Worm hermaphrodite cells reduce production of the proteins encoded by each of their X chromosomes by half, so they end up with the same amount as male cells.

Mammals use X inactivation, in which each female cell shuts off one of its X chromosomes and only uses the other. Which X chromosome is shut off (the paternally inherited one or the maternally inherited one) is random and independent within each cell. So women are all genetic mosaics: Their cells are not all making the same proteins since some of their cells use one of their X chromosomes and some of their cells use the other.

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