Clinical trial will attempt growing new liver from lymph node

Enlarge (credit: Lygenesis)

For the first time, scientists are attempting to grow a new, miniature liver inside of a person. It sounds like science fiction; in fact, the idea was the plot of a Grey’s Anatomy episode that aired in 2018. Now, biotech company LyGenesis is trying to turn the concept into reality.

Today, LyGenesis announced that an initial volunteer has received an injection of donor cells to turn one of their lymph nodes into a second liver. The procedure was carried out in Houston on March 25 as part of a clinical trial that will test the experimental treatment in 12 adults with end-stage liver disease.

These patients usually require a liver transplant, but donor organs are in short supply. LyGenesis is hoping to spur the growth of enough healthy liver tissue that patients don’t need a transplant. “We’re using the lymph node as a living bioreactor,” says Michael Hufford, cofounder and CEO of Pittsburgh-based LyGenesis. He says just 10 to 30 percent in additional liver mass could have meaningful effects for patients with end-stage liver disease.